Archives For genomics

The New Bio-Citizen: How the Democratization of Genomics Will Transform Our Lives from Epidemics Management to the Internet of Living Things

The attributes of a new bio-citizen, in an internet of living things, look like this: scientists, patients, congressmen, employees —everyone—will be analyzing the DNA of their own bodies and the living species surrounding them, by running algorithms through their data sets on shared cloud labs. Portable genomic sequencers, the size of a USB and connected to our smartphones, would become an integral part of our most crucial socio-technical systems from agro-food facilities, airports, battlefields, hospitals and our DIY home labs. These DNA-reading sensors would identify the nature, transmission roads and mutations of deadly viruses, engineered bacteria and forgotten lethal pathogens that could be soon freed by the melting permafrost. In their home, individuals would have access to liquid biopsies, blood test that could track their most vital biomarkers and identify, at early stage, the pieces of DNA shredded by a cancer tumor or a viral agent. If millions of citizens were streaming these data to the cloud, citizens would build the most powerful data set for preventive and precision medicine. The genetic identity of any living thing, then, acquires a second life on the internet; it is The Internet of Living Things.

In this beginning of 21st century, are we equipped to manage the complex and uncertain ethical, security and governance entanglements coming from the Internet of Living Things? (READ MORE)

 

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World Economic Forum|How to Optimize Human Biology:  Where Genome Editing and Artificial Intelligence Collide

Genome editing and artificial intelligence (AI) could revolutionize medicine in the United States and globally. Though neither are new technologies, the discovery of CRISPR in genome editing and advances in deep learning for AI could finally grant clinical utility to both. The medical use of these technologies individually could result in their eventual combined use, raising new and troubling ethical, legal, and social questions. If ongoing technical challenges can be overcome, will the convergence of AI and CRISPR result in practitioners ‘optimizing’ human health? And could viewing human biology as a machine result in a willingness to optimize biology for reasons other than health alone? Given the rapid technical progress and potential benefits of genome editing and AI, answering these questions will become more pressing in the near future. Such concerns apply not only to the United States, but to the international medical community. Notably, China has demonstrated its desire to be a global leader in both genomics and AI, which could indicate the potential of these technologies to converge in China soon. What form should the international governance of these technologies take and how will it be enforced? To ensure responsible progress of genomics and AI in combination, a balance must be struck between promoting innovation and responding to ethical, social, and moral quandaries. (READ MORE)